You didn’t mention what boat you have, what brand of electronics (presumably Garmin since you mentioned LS), what bodies of water, or how much you rely on your electronics… I believe those factors will dictate how satisfied you would be with a 16” unit running splits.
I have a Ranger Z521L, so I have quite a bit of room to work with. I have a Lowrance ecosystem, and run two 12” HDS Lives at the bow and a 16” HDS Live at the console.
I fish Mead and Mohave mostly, so they are deep and clear. I rely on all aspects of my electronics - mapping, 2D, SI and AT2. I have one unit more or less dedicated for AT2, and run various splits on the second bow unit depending on what I’m doing and where I’m doing it.
The Lowrance units are fully configurable regarding split screens and adjustments, so I have a number configured for my console unit. Being able to adjust the splits almost infinitely is a huge advantage, and makes the single console unit a perfect fit for me.
Due to this, I certainly believe I could run a single 16” at the bow, but prefer dual units. I may actually pick up a deal on a used 16” if I can find one and swap out one of my 12’s, but I’ll still run dual units.
One of the best features of the HDS units is the configurable buttons for favorite pages… makes it simple to swap to specific screens with the press of a single button.
Good luck with your decision, and Merry Christmas!