When I was younger, it wasn't a problem to get up at Zero Dark Thirty, drive 4 hours, fish and drive the four hours back. Now, overnight, probably two hours, which would be up to the Poconos. That use to be the most common day trip we did, but one of the guys I fish with brought a house near Lake Wallenpaupack last year, so now we can fish all day and crash at his place and head back the next day.
I make a 7 hour drive to my sister's eventual retirement place in Vermont. That's usually a three or four day stay before I head back. 7 hours is about my limit on how far I can drive in a day now.
The longest drive this year will be a trip to a lodge in NE Ontario. Realistically it's a 13 to 14 hour drive. The first time my buddy I went up there, we drove straight through. That was in 1986. This year he is going up with me again. Right now we're debating whether we want to drive almost straight through, 12 hours or stop after about 9 hours. Either way it's a two day drive.