On a main river the location is more important than the bait, line, or anything else. If you're watching people catch fish pay attention to where they are hooking them as opposed to what they are hooking them on. You can be off two feet and never get touched.
Drag a 1/2 - 3/4oz football jig around or a 3/4oz C-rig with a Rage Craw behind it and figure out the bottom. If you're fishing the same spot over and over with zero results but you know fish are there then you haven't learned your spot.