I have fished the Ned a lot and unknowingly midwest finesse for many years on the river, sub 4" baits on a light ball head jig, with great hookup rates.
I use fireline, sometimes with a flouro leader on mostly a medium action ugly stick, but have also had the same success with a medium/fast tipped stick too.
The one thing I do though is always fish the bait on a fairly tight line and set the hook any time I feel a bump. I refuse to fish baits on slack line, or letting a fish take a bait for a bit before I set the hook, because of potential deep hooking chances. Also on the river line watching is tough with all the different currents, and if you don't set the hook right away the fish is gone.
Almost all of my fish, lake and river and hooked in the top of the mouth which seems to be the toughest part of the mouth, which I think helps my landing percentage.