Yup, I am having a cyst removed for the 2nd time in 6 years. It has caused pain and weakness in my wrist, but I always found ways to work around it. With a spinning rod, I would let the butt end of the rod either anchor against my body or rest against my forearm to ease the pressure on my wrist when fighting a big fish.
I did have to give up golf because of this, because the wrist wasn't strong enough to close the club face at impact. Thankfully, while I am sure it limits some things, it hasn't forced me to stop fishing.
Once this is clear it is possible there is the start of arthritis too, but at 45 I hope not.