What ever feels best to you. I'm right-handed and all my reels are righty. From age 4 to 13 I fished a Zebco 33. I learned the fundamentals of all basic presentations and retrieves using my left hand to control the rod thanks to the right-hand retreive of the Zebco. Casting with my non-dominant hand is almost as ugly looking as trying a finesse presentation with my dominant hand. I'm right handed and trying to shakey head with my right arm is tougher than brushing my teeth with my left hand hand! Go figure!
Now, if you want a real debate, ask me how to hold a knife and fork!