Seat time seat time seat time - and by that I mean really get to know and understand the benefits and limitations of each pedal-drive kayak offering (ie: Hobie Mirage Drive and Native Propel). Currently, the Native line offers the Propel in the Slayer 13 and 10 models, and the Mariner 10 and 12.5. The Hobie lineup has Mirage Drives installed in the following hulls: Outback Sport (9'), Outback (12'1"), Revolution 11 (11'6"), Revolution 13 (13'5"), Revolution 16 (16'), Pro Angler 12 (12') & 14 (13'8"), Inflatable i9S (9'), i12S (12') and Adventure Island (16'7"). They also have tandem drive options as well (I wouldn't recommend it for spousal outings, but fishing buddies would work ) in the regular rotomolded, as well as the Pro Angler, Inflatable and Sailing hulls.
What I mean by seat time is not just how the kayak hull feels on the water, but you need to understand all the nuances of how to maneuver the hull in the bodies of water you fish. If you fish primarily heavy wooded, matted cover with thick vegetation, then a drive system is likely not the best option for you. If you are a big sight casting angler, then your hull choices in both lineups decrease based upon your own equilibrium and the respective hull's stability characteristics.
Lastly, you need to understand your body limitations when it comes to the range of motion that is required to utilize both drive systems. The Propel drive is a bicycle style pedaling motion. While that seems natural to most, what many do not consider is the angle of their hips and the ability to pedal using that motion for an extended period of time. The same goes for the Hobie Mirage Drive. The pedaling motion is a linear motion with shorter leg travel or range of motion required.
In both drive systems, if you do not position the seat properly or you have poor posture, you will likely induce discomfort over the course of an outing.
As far as loading the various hulls, all I can tell you is that I loaded my two different Pro Angler 14's atop two different vehicles over the last three years - my first PA14 was loaded countless times atop my Dodge Grand Caravan.
And my 2014 PA14 was loaded last year atop my Honda CRV - it's not as hard as people make it out to be. I have a torn labrum and limited range of motion and loaded them both with ease.