yes and no, I used to fish my uncle's ponds, which btw are a lot smaller than your lake, 3-4 times a week, the fish "learned" to avoid certain lures quite fast, what murdered them one week didn't work the next weeks, it was a matter of just giving that lure a rest for a couple of months to become effective again. However, certain lures worked consistently, week after week, soft plastic worms and grubs worked with just a slight change of presentation.