I don't know if any of you have ever heard of Barrett's Esophagus, this is a weakening of the muscle around the valve that closes the esophagus. I've had heartburn, ulcers, Acid Reflux, even waking up in the middle of the night to vomit stomach acid for over 17 years. My uncle had it so bad that he developed Esophageal Cancer. If you have Acid Reflux you must get checked for it. He had it so bad that they had to cut out his Esophagus and reattach his stomach to the bottom of the valve. Very painful and life altering. Best thing I've found is losing weight, not eating late, taking prevacid every night and wearing my sleep apnea machine at night. I've tried all of the above mentioned drugs, and thats what finally worked for me. I know you guys may think this sounds crazy, but it's kinda funny, my mom's maiden name was Barrett. Rather ironic don't you think?