LeBron,
I have a 2008 Tundra Limited, 4x4, 5.7L, tow pkg., don't know the gear ratio, 3" lift kit, 35" tires. If I drive normal and don't accelerate aggressively at take off I get 12.5 to 13.5 MPG. If I drive it slightly hard that drops to about 11.5 to 12.5 MPG. If I baby it I can get about 13.5 to 14.5 MPG. Towing the boat (16.5' Tracker) it gets about 11.5 MPG. These figure are based on driving a combination of city and highway. The truck has plenty of power to tow a much heavier load but I don't know how bad it will impact the mileage.
Good Luck,
Dave