With recent events in our area it has become something that consumes my thoughts, I have guns that can protect my family in the house but not anything you can carry around or get to in a hurry if need be.
Handguns have become really expensive, which has become one more determining factor added into the massive decision making process, another has become insurance, not for the gun but for yourself, depending on the laws in your area, should you choose to protect yourself with an open and or concealed carry no matter which you choose, there is an underlying issue of lawsuits from a corrupt justice system fighting for the criminals rights, should you ever have to defend yourself you could be brought to court on charges, make sure you add this to your list of things to consider.
I still have not purchased one as of yet, I have however talked to many law enforcement officers, many military personnel, fired and serviced a lot of their hand guns that they use, gone to I don't know how many gun shops to find the right gun that would be comfortable for use and have complete confidence in, a lot of these people will try to sell you what they think you need, don't do that, do what is right for you, explore as many options as you can, I thought I really wanted a Glock, their name and dependability are about as good as it gets but the breakdown process on the models I am interested in does not allow me to release the upper portion (the slide) with ease, my fingers are just big to grab those tiny little release tabs, it's simple things like this that can later on make you wish that you would have put that hard earned money into something else, take your time and handle as many hand guns as you can before you take that leap, make sure your comfortable with everything about it, we have a gun store here in Va. that allows you to fire any weapon in any caliber you want, that little extra money spent in places like this can make all the difference in choosing a hand gun and caliber that fits you best, you must have confidence and be comfortable with your choice, once you do make that choice, don't skimp on the practice and the training either, hope that helps a bit for when you do decide.
Edit: I forgot to include the one I chose for CC and home defense, 45 cal. Sig Sauer P250 full size