I also use a 2/0 or 3/0 ewg gamagatsuuuuuuuu. however there are times when i will downsize to a 1/0. i feel it falls more naturally and the bass tend to take it in better. Also for me, the smaller hook tend to penatrate easier.
As far as hookset, when I feel a bump I reel down and set straght up. If the bass seem to be very subtle I will gently lift the rod tip to see if there is pressure. If there is I will use the set descibed above and by others. hope this helps.