Opie, are you talking about getting less or more bites with braid in clear water or physically sticking the fish with braid? If it's the number of bites you get, I agree with the thought that active fish probably don't care but finicky/pressured fish might. I also agree with Gulf in that you really do have to be confident in your complete setup; from rod to reel to line to knots, hook, baits, scents etc... Personally, I want the best shot at getting every single bite I can so I use a fluoro leader all the time. I have never had an issue with any part of this setup so why not?