Depends on the time of year. Right now, forget about the flats and sloughs. You have to be right IN the channel or right NEXT to it on the drop. Fish bridge pilings, for instance. Look for sharp drops right into the channel. Also, marinas can be good sometimes.
As for baits - flish plastics (tubes, grubs, spider jigs, dropshots), topwaters and rat-l-traps right now.
And in the summer, I don't have clue where the beefy largemouth go. I've searched for them and can only find their babies.
Your lures and locations will change in the spring and fall.